Insulin Resistance, Mitochondrial Health, and the Metabolic Roots of Cancer and Aging
Why Metabolism Is the Missing Link in Modern Medicine Cancer prevention, longevity, and metabolic health are usually discussed as separate domains. Oncology focuses on mutations. Aging research focuses on senescence and epigenetics. Metabolic health is reduced to weight, glucose, or cholesterol. This siloed thinking misses a deeper unifying driver. The common thread connecting cancer risk, cancer outcomes, and biological aging is metabolic signaling —specifically insulin resistance and mitochondrial dysfunction. This article lays out a single, coherent framework: Insulin resistance drives mitochondrial dysfunction, which erodes metabolic flexibility. That environment accelerates aging and creates fertile ground for cancer. 1. Insulin Resistance Is Not a Blood Sugar Problem Insulin resistance (IR) is often framed as a pre-diabetic condition. In reality, it is a whole-cell signaling disorder . When insulin signaling is impaired: Cells fail to take up glucose efficiently Circulating insul...