The Medical Advisor

Abstract Background: Aging and major chronic diseases—including type 2 diabetes, cardiovascular disease, neurodegeneration, and certain cancers—share overlapping metabolic abnormalities. Emerging evidence suggests that disturbances in redox balance (NAD⁺/NADH), insulin signaling, and nutrient-sensing pathways (AMPK and mTOR) may represent convergent upstream mechanisms. Objective: To synthesize mechanistic and translational evidence into a unified systems biology model describing how chronic nutrient excess and impaired metabolic oscillation influence aging and disease pathogenesis. Methods: Narrative synthesis of peer-reviewed literature across redox biology, mitochondrial physiology, insulin signaling, geroscience, and neurodegeneration. Emphasis was placed on mechanistic plausibility, human interventional data where available, and cross-disease convergence. Results: Chronic energy surplus is associated with altered NAD⁺/NADH ratios, mitochondrial dysfunction, hyperinsulinemia, p...

Introduction The majority of Americans might be misled by official health recommendations to eat “healthy” vegetable oils. Even the term “vegetable oil” is misleading because it gives you the impression that you are receiving vegetable micronutrients when these oils are actually highly toxic, industrially-processed seed oils. Seed oils are some of the most dangerous items you could eat. Everyone should be informed about seed oils and linoleic acid. Tucker Goodrich and Dr Mercola discussed what will be the topic of Dr Mercola's next book, namely linoleic acid (LA), which he believed is likely the leading contributing cause of virtually all chronic diseases we've encountered over the last century. Unfortunately, this is a topic that most clinicians and health care practitioners who focus on natural medicine have only a superficial understanding of. In a 2025  mechanistic review, published in Advances in Redox Research , Dr Mercola broke down exactly how Linoleic Acid ...