The Medical Advisor

Medically Reviewed by: OneDayMD Editorial Team Last Updated: April 2026 Abstract Background: Repurposed antiparasitic agents, including ivermectin and benzimidazoles (fenbendazole and mebendazole), have gained attention for their potential anticancer properties, particularly in colorectal cancer. Preclinical studies suggest these agents may exert antitumor effects through mechanisms such as inhibition of cell proliferation and disruption of key oncogenic pathways, including Wnt/β-catenin signaling. Objective: To summarize and evaluate a compilation of case reports describing the use of ivermectin and benzimidazole-based regimens in patients with colorectal cancer, with a focus on advanced-stage disease. Methods: This review analyzes a curated series of 56 case reports involving patients with colorectal or related gastrointestinal cancers treated with ivermectin in combination with fenbendazole or mebendazole, often alongside standard therapies such as chemotherapy. Reported outc...